Friday, 12 May 2017

Anti Psychotics

Schizophrenia requires lifelong treatment, even when symptoms have subsided. Treatment with medications and psychosocial therapy can help manage the condition. In some cases, hospitalization may be needed.
Medications are the cornerstone of schizophrenia treatment, and antipsychotic medications are the most commonly prescribed drugs. They're thought to control symptoms by affecting the brain neurotransmitter dopamine.
The goal of treatment with antipsychotic medications is to effectively manage signs and symptoms at the lowest possible dose. The psychiatrist may try different drugs, different doses or combinations over time to achieve the desired result. Other medications also may help, such as antidepressants or anti-anxiety drugs. It can take several weeks to notice an improvement in symptoms. Because medications for schizophrenia can cause serious side effects, people with schizophrenia may be reluctant to take them. Willingness to cooperate with treatment may affect drug choice. For example, someone who is resistant to taking medication consistently may need to be given injections instead of taking a pill.
Second-generation antipsychotics
These newer, second-generation medications are generally preferred because they pose a lower risk of serious side effects than do first-generation antipsychotics. Second-generation antipsychotics include:
Aripiprazole (Abilify), Asenapine (Saphris), Brexpiprazole (Rexulti), Cariprazine (Vraylar), Clozapine (Clozaril), Iloperidone (Fanapt), Lurasidone (Latuda), Olanzapine (Zyprexa), Paliperidone (Invega), Quetiapine (Seroquel), Risperidone (Risperdal), Ziprasidone (Geodon)
First-generation antipsychotics
These first-generation antipsychotics have frequent and potentially significant neurological side effects, including the possibility of developing a movement disorder (tardive dyskinesia) (involuntary repetitive body movements) that may or may not be reversible. First-generation antipsychotics include: Chlorpromazine, Fluphenazine, Haloperidol and Perphenazine.
These antipsychotics are often cheaper than second-generation antipsychotics, especially the generic versions, which can be an important consideration when long-term treatment is necessary.
PSYCHOSOCIAL INTERVENTION
Once psychosis recedes, in addition to continuing on medication, psychological and social (psychosocial) interventions are important. These may include:
·         Individual therapy. Psychotherapy may help to normalize thought patterns. Also, learning to cope with stress and identify early warning signs of relapse can help people with schizophrenia manage their illness.
·         Social skills training. This focuses on improving communication and social interactions and improving the ability to participate in daily activities.
·         Family therapy. This provides support and education to families dealing with schizophrenia.
·         Vocational rehabilitation and supported employment. This focuses on helping people with schizophrenia prepare for, find and keep jobs.
Most individuals with schizophrenia require some form of daily living support. Many communities have programs to help people with schizophrenia with jobs, housing, self-help groups and crisis situations. A case manager or someone on the treatment team can help find resources. With appropriate treatment, most people with schizophrenia can manage their illness.
Hospitalization
During crisis periods or times of severe symptoms, hospitalization may be necessary to ensure safety, proper nutrition, adequate sleep and basic hygiene.
Electroconvulsive therapy
For adults with schizophrenia who do not respond to drug therapy, electroconvulsive therapy (ECT) may be considered. ECT may be helpful for someone who also has depression.

SELF MANAGEMENT

Coping and support
Coping with a mental disorder as serious as schizophrenia can be challenging, both for the person with the condition and for friends and family. Here are some ways to cope:
·         Learn about schizophrenia. Education about the disorder can help motivate the person with the disease to stick to the treatment plan. Education can help friends and family understand the disorder and be more compassionate with the person who has it.
·         Join a support group. Support groups for people with schizophrenia can help them reach out to others facing similar challenges. Support groups may also help family and friends cope.
·         Stay focused on goals. Managing schizophrenia is an ongoing process. Keeping treatment goals in mind can help the person with schizophrenia stay motivated. Help your loved one remember to take responsibility for managing the illness and working toward goals.
·         Ask about social services assistance. These services may be able to assist with affordable housing, transportation and other daily activities.

·         Learn relaxation and stress management. The person with schizophrenia and loved ones may benefit from stress-reduction techniques such as meditation, yoga or tai chi.

Anti Depressants

Occasional feelings of sadness or depression are experienced by most people at some point in life. Feeling sad is a normal human response to difficult situations such as loss of a loved one, financial troubles, or problems at home. These feeling usually last for a few days. However, when these feelings turn into intense sadness, or a person feels helpless, worthless, and hopeless, and last for weeks or longer, it could be due to clinical depression. Depression is a common but serious mental illness that affects millions of Americans. The symptoms of depression interfere with daily life and cause significant pain to the patient and their loved ones. Although with proper treatment even severe symptoms of depression can get better, many people never seek treatment due to the societal stigma associated with mental illnesses.
Common symptoms of depression include the following:
·         Sadness, unhappiness
·         Loss of interest in enjoyable activities
·         Anger, frustration, irritability
·         Sleep changes (too much or too little)
·         Feelings of worthlessness
·         Thoughts of death or suicide; suicidal attempts
·         Weight loss or weight gain
CLASSES OF ANTIDEPRESSANTS
  1. Selective serotonin reuptake inhibitors (SSRIs)
  2. Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  3. Tricyclic antidepressants (TCAs)
  4. Monoamine oxidase inhibitors (MAOIs)
  5. Atypical agents
Side Effects of SSRI’s
Nausea, insomnia, dizziness, weight gain or loss, tremors, sweating, anxiety and restlessness, decreased sexual drive, drowsiness or fatigue, dry mouth, constipation, Headache etc.


Side Effects of TCA’s
Blurred vision, Constipation, Increased appetite, nausea, weight gain, loss of sex drive, dry mouth, difficulty urinating, sun sensitivity and increased heart rate etc.
Side Effects of SNRI’s
Nausea, anxiety, restless, insomnia, sexual dysfunctioning, gastric upset, sweating, tremor, dizziness, weight loss, decreased sex drive, fatigue, dry mouth etc.
Side Effects of Atypical Anti Depressants
Dry mouth, nervousness, seizure at high dose, nausea, fatigue, weight gain, sleepiness, nervousness, dry mouth and blurred vision etc.
Side Effects of Monoamine Oxidase Inhibitors
Nausea, headache, stiff neck, dry mouth, dizziness, insomnia, weight gain, sleepiness at day time, sexual problems, headache etc.
Selective serotonin reuptake inhibitors (SSRIs)
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants. They are highly effective and generally cause fewer side effects than the other antidepressants. SSRIs help to alleviate symptoms of depression by blocking the reabsorption or reuptake of serotonin in the brain. Serotonin is a naturally occurring neurotransmitter (chemical) that is used by brain cells to communicate. As SSRIs mainly affect the levels of serotonin and not levels of other neurotransmitters, they are referred to as “selective.
SSRI generic and brand names
Fluoxetine (Prozac), Fluvoxamine (Luvox), Sertraline (Zoloft), Paroxetine (Paxil), Escitalopram (Lexapro), Citalopram (Celexa)
Serotonin norepinephrine reuptake inhibitors (SNRIs)
            Serotonin norepinephrine reuptake inhibitors (SNRIs) work by blocking the reabsorption of the neurotransmitters serotonin and norepinephrine in the brain. They may also have an effect on other neurotransmitters.

SNRI’s generic and brain names
Desvenlafaxine (Pristiq), Duloxetine (Cymbalta), Levomilnacipran (Fetzima), Milnacipran (Ixel, Savella), Tofenacin (Elamol, Tofacine), Venlafaxine (Effexor)
Tricyclic antidepressants (TCAs)
Tricyclic and tetracyclic antidepressants, also called cyclic antidepressants, are among the earliest antidepressants developed. They're effective, but they've generally been replaced by antidepressants that cause fewer side effects. However, cyclic antidepressants may be a good option for some people. In certain cases, they relieve depression when other treatments have failed.
Cyclic antidepressants ease depression by impacting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, cyclic antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression. Cyclic antidepressants block the absorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and nor epinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects. The Food and Drug Administration (FDA) approved these cyclic antidepressants to treat depression:
Tricyclic antidepressants:
Amitriptyline, Amoxapine, Desipramine (Norpramin), Doxepin, Imipramine (Tofranil), Nortriptyline (Pamelor), Protriptyline (Vivactil) and Trimipramine (Surmontil)
A Typical Antidepressants
Atypical antidepressants ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, atypical antidepressants work by ultimately effecting changes in brain chemistry and communication in brain nerve cell circuitry known to regulate mood, to help relieve depression. Atypical antidepressants change the levels of one or more neurotransmitters, such as dopamine, serotonin or norepinephrine.
Bupropion (Wellbutrin, Forfivo XL, Aplenzin), which under the name Zyban is used to aid in smoking cessation, Mirtazapine (Remeron), Nefazodone, Trazodone, which is also used to treat insomnia and Vortioxetine (Trintellix).
Monoamine Oxidase Inhibitors
Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed. They're effective, but they've generally been replaced by antidepressants that are safer and cause fewer side effects. Use of MAOIs typically requires diet restrictions because they can cause dangerously high blood pressure when taken with certain foods or medications. In spite of side effects, these medications are still a good option for some people. In certain cases, they relieve depression when other treatments have failed. Antidepressants such as MAOIs ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells. Like most antidepressants, MAOIs work by ultimately effecting changes in the brain chemistry that are operational in depression. An enzyme called monoamine oxidase is involved in removing the neurotransmitters norepinephrine, serotonin and dopamine from the brain. MAOIs prevent this from happening, which makes more of these brain chemicals available to effect changes in both cells and circuits that have been impacted by depression. MAOIs also affect other neurotransmitters in the brain and digestive system, causing side effects. MAOIs are sometimes used to treat conditions other than depression, such as Parkinson's disease.
The Food and Drug Administration (FDA) has approved these MAOIs to treat depression:
Isocarboxazid (Marplan), Phenelzine (Nardil), Selegiline (Emsam) and Tranylcypromine (Parnate)

Selegiline is available as a skin (transdermal) patch. Using a patch may cause fewer side effects than MAOIs taken by mouth. If you're using the lowest dose patch, you may not need diet restrictions, but ask your doctor.

Monday, 1 May 2017

Endocrine System, Hormones and Their Functions




Glands and Hormones
Functions of Hormones
Posterior pituitary Gland

Antidiuretic (ADH)
Stimulates water reabsorption by kidneys
Oxytocin
Stimulates uterine muscle contractions and release of milk by mammary glands
Anterior Pituitary

Thyroid stimulating (TSH)
Stimulates thyroid
Adrenocorticotropic (ACTH)
Stimulates adrenal cortex
Gonadotropic (FSH, LH)
Egg and sperm production, sex hormone production
Prolactin (PRL)
Milk production
Growth (GH)
Cell division, protein synthesis and bone growth
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Thyroxine (T4)
Increase metabolic rate, regulates growth and development
Triiodothyronie (T3)
Increase metabolic rate, regulates growth and development
Calcitonin
Lowers blood calcium level
Parathyroids

Parathyroid (PTH)
Raises blood calcium level
Adrenal Cortex

Glucocorticoids (cortisol)
Raise blood gluclose level, stimulates breakdown of protein
Mineralocorticoids (aldosterone
Reabsorb sodium and excrete potassium
Sex Hormones
Stimulates reproductive organs and brings on sex characteristics
Adrenal Medulla

Epinephrine
Released in emergency situations, raises blood glucose level, “fight or flight” response
norepinephrine
Released in emergency situations, raises blood glucose level, “fight or flight” response
Pancreas

Insulin
Lowers blood glucose levels, promotes formation of glycogen
Glucagon
Raises blood glucose levels
Testes

Androgens (testosterone)
Stimulates male sex characteristics
Ovaries

Estrogen
Stimulates female sex characteristics
Progesterone
Stimulates female sex characteristics
Pineal Gland

Melatonin
Controls circadian and circannual rhythms, possibly involved in maturation of sexual organs